Infectious Complications in Patients With Chronic Granulomatous Disease

Chronic granulomatous disease: a review of the infectious and inflammatory complications

Chronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formation of granulomas in tissue. The disease is the result of a disorder of the NADPH oxidase system, culminating in an inability of the phagocyte to generate superoxide, leading to the defectiv...

gastrointestinal manifestations of patients with chronic granulomatous disease

chronic granulomatous disease (cgd) represents a group of inherited disorders of phagocytic system, manifesting recurrent infections at different sites. the present study was accomplished in order to determine the gastrointestinal manifestations of cgd patients. fifty-seven patients (38 males and 19 females) with cgd, who had been referred to three immunodeficiency referral centers in iran, wer...

Management of infectious complications in patients with chronic lymphocytic leukemia.

Infections remain a major cause of morbidity and mortality in patients with chronic lymphocytic leukemia (CLL). The pathogenesis of these complications is related to immune defects inherent to the primary disease as well as to therapy-related immunosuppression. The spectrum of infections seen has evolved with the therapeutic use of purine analogs, which induce specific cellular immune defects, ...

Anakinra for the inflammatory complications of chronic granulomatous disease.

Pulmonary manifestations in adult patients with chronic granulomatous disease.

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by failure of superoxide production in phagocytic cells. The disease is characterised by recurrent infections and inflammatory events, frequently affecting the lungs. Improvement of life expectancy now allows most patients to reach adulthood. We aimed to describe the pattern of pulmonary manifestations occurring during adu...